| abstract |
The invention relates to novel piperazine derivatives of formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, especially malaria. wherein X represents -(CH2)o-2 - or -C(=O)-; n represents the integer 0, 1 or 2; R1-R4 as described in claim 1 |