| abstract |
The instant invention provides compounds of Formula I which are leukot.pi.ene biosynthesis inhibitors. Z is a fused (optionally sulfo-oxidized) thiophen ring or a fused pyrrol ring R2-R4 are selected from a variety of substituents Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti¬ inflammatory and cytoprotective agents. |