abstract |
Provided herein are benzothiazol and thizolopyridine derivatires which are sirtuin-modulating compounds and methods of use thereof . The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/ or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent . |