abstract |
The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: (see formula A) (see formula B), Such compounds possess useful antimicrobial activity, particularly against methicillin resistant Staphylococcus Aureaus (MRSA) for which there is an urgent need. The variables R2, R3, R5, R6, R7, and R9 shown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/ or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections, including MRSA, in patients. |