http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2615315-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0efa077d881a96aeb1e29b21ef1bbb58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-12 |
| filingDate | 2006-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80a9297ba5d2f74b2c23e65565a4a51a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0179ebbd8d258304cef1ed79846d0a52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47635a602c79a15755bbaf9e5cc383b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5814c4982ff281ebe1a5dfd1c879b5f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2237c394eff1b422d1221006d764df13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_805f932ae07c6252dcd00dee70b0be11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_898acfc8eee6fcd56e22b8054b1545b8 |
| publicationDate | 2007-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2615315-A1 |
| titleOfInvention | Use of dimethyl disulfide for methionine production in microorganisms |
| abstract | The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a .DELTA.metF organism or a .DELTA.metE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/Met.EPSILON. and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A .DELTA.metF .DELTA.metB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS. |
| priorityDate | 2005-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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