| abstract |
It is intended to provide a compound represented by the formula (I) (I) (wherein R represents an alkyl group having 1 to 6 carbon atoms substituted with 2 hydroxyl groups, Cy represents a bicyclic or tricyclic aliphatic carbocyclic group having 6 to 10 carbon atoms which may have a substituent in some cases). The compound acts as a nociceptin receptor antagonist and is useful as, for example, a narcotic analgesic resistance reversal agent; a reversal agent for narcotic analgesic dependency or withdrawal syndrome; an analgesic action enhancing agent; an anti-obesity agent or an appetite control agent; an improving agent or preventive agent for decline in learning and memory abilities or dementia symptom; an improving agent for cognitive function in the developmental stage; a therapeutic agent for schizophrenia; a therapeutic agent for regressive neurodegenerative disease; an antidepressant agent or an emotion control agent; a therapeutic agent or preventive agent for diabetes insipidus; a therapeutic agent or preventive agent for polyuria; a therapeutic agent for hypopiesis and the like. |