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filingDate 2006-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e991725f77abfe1d588525fc8e88d35b
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publicationDate 2018-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2614046-C
titleOfInvention Methods of controlling properties of therapeutic proteins, fc-containing therapeutic proteins of the g2s2 alpha-(2,3)-sialylated glycoform, and uses thereof
abstract The properties of an Fc-containing protein, for example, an antibody, are controlled by altering the sialylation of the oligosaccharides in the Fc region. The modified Fc-containing proteins have therapeutic utility in diseases or conditions in which it is desirable to control the affinity for one or more of the FcgRI, FcgRIIA, and FcgRIIIA receptors, ADCC activity, macrophage or monocyte activation, serum half-life, and avidity.
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ12669
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ97SU1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0CZ46
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0U1U0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO31682
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID23778370
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID6559468
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8TK19
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0CZ47
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ54RF5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ749N5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB9DSX1
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3235845
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID914631
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2W2L1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0CW04
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0CW05
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8FK84
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8Y449
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7IY64
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6FD71
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID24139
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ54QJ9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC4ZUS8
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID14130
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5B3G6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7V9Y1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4TLL5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0RP54
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ129C6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2VHN8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9BFZ7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5E598
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5YHP1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2SL21
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8DGH7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8FP04
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6UW35
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ46GB9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP44406
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID4928411
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3JVB1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ28UT2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2FG27
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID6640169
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO32258
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC4KHI0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0HZ05
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB3R0X7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0I3R3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP16199
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ46IS8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP70789
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA0QSH8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2YUK8
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID163606
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8XWE1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6FIS9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2YWD9
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID15894
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC3PP86
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3233940
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID6579983
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID37501
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC4K7W8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6UP41
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3788611
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8K9M3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0CL98
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID281350
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID403657
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7VII5
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419524992
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0CL99
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO14466
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ289M4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC3PL31
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID40154140
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8K980
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419525056
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID105589237
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1U2U2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC4KZM5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9JTM0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0VSA9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8G092
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7CIZ3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8AZH2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ6G2Y6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ46289
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5PFK8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2HPZ3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP23253
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5DC72
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO26135
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8G3Z8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP16278
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7LVN6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9JT07
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2FT48
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ606F1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ7V526
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID10705
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID64968
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5UCQ6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP67923
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1UBR9
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419588330
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1A778
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8A1G8
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID56943037
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8GGL2
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID281766
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5Y0N3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5YDP7
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID782652
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9BWI1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ601J4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC3P9S6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP29188
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5Y7W0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7V109
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5F2U0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP67907
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0V9Q9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5R7P4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2G8V7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ56301
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ55863
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7M0C6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8XZJ0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9UX83
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4W7D2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ72I25
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8YHL9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1A8R9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6T5N7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1TQ96
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0A6A3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ57572
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8X685
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO24706

Total number of triples: 2039.