http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2612211-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G83-004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-10 |
| filingDate | 2006-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef61f2b42131d7017adca4f1fa0ed08d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b44364dc731f550b8bbe770acbbf5a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff6ef08736c5b2961abdbbaae8daa823 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_360cadd2867db96d3154ba8552606bb1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cacef2aa90417a5545cee8a4e91330af |
| publicationDate | 2007-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2612211-A1 |
| titleOfInvention | Modified poly(propylene-imine) dendrimers and their use as transfection agents for anionic bioactive factors |
| abstract | The present invention is concerned with modified poly-(propylene imine) dendrimers, comprising cationic internal ammonium groups and external non-toxic endgroups, pharmaceutical compositions comprising said dendrimers, methods for the production of said dendrimers and their use as transfections agents for anionic bioactive therapeutic factors, for use in gene therapy, in particular for the treatment of cancer. The modified poly-(propylene imine) dendrimer of generation 1, 2, 3, 4 or 5, also comprising incomplete dendrimers and mixtures thereof, comprising external end groups and internal amine functions are characterized in that: (a) substantially all external endgroups are groups of formula (I) wherein R is a radical selected from the group of C1-10alkyl, polyethylene glycol radical and polyethylene glycol gallyl radical ; and (b) substantially all internal amine functions are quaternary cationic ammonium functions. Most preferred are the quaternized compounds DAB-dendr-(NHCOCH3)4, DAB-dendr-(NHCOCH3)8, DAB-dendr-(NHCOCH3)16, DAB-dendr-(NHCOCH3)32, DAB-dendr-(NHCOCH3)64, DAB-dendr-(NHCOPh((EO)4OMe)3)4, DAB-dendr-(NHCOPh((EO)4OMe)3)8, DAB-dendr-(NHCOPh((EO)4OMe)3 )16, DAB-dendr-(NHCOPh((EO)4OMe)3 )32 and DAB-dendr-(NHCOPh((EO)4OMe)3 )64. |
| priorityDate | 2005-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.