| abstract |
The present invention relates to binding molecules that specifically bind to the human Fc gamma receptor expressed on the surface of natural killer (NK) cells and macrophages (i.e. Fc.gamma.RIIIA), and in particular binding molecules that specifically bind the A form Fc.gamma.RIII but do not bind to the B form of Fc.gamma.RIII, as well as to the use of such binding molecules in the diagnosis and treatment of disease. The invention further extends to polynucleotides encoding such binding molecules, host cells comprising such polynucleotides and methods of producing binding molecules of the invention using such host cells. |