| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ee33b0e3e7398cf6fc957eeee59d510
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40ca166289225aa2dc76e1c5abdac8d3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
2006-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a14c40344786faf4c5b80234e0f038f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6452a678faf023a8e9b73db1c42b9f1d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbd882a59693d148afd85de1b666d0ed |
| publicationDate |
2006-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2607832-A1 |
| titleOfInvention |
Auxiliary method for diagnosis and therapy of cancer with nucleolin |
| abstract |
Based on the discovery that nucleolin is a specific receptor to endostatin, in the invention a kit is provided. The kit is used for detecting and screening the cancerous types and individuals that are adapted to be treated by using endostatin and other angiogenesis inhibitors. Specially, the detection kit can include the antibody to nucleolin and DNA or RNA combined with coding nucleic acids of nucleolin. In the invention, a screening method for angiogenesis inhibitors is provided, especially those similar inhibitors to endostatin. Furthermore, methods for specifically inhibiting growth of endothelial cells and generation of tumor blood vessels are provided by coupling cytotoxin such as tumor necrosis factor .alpha. with the antibody to nuleolin. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011123945-A1 |
| priorityDate |
2005-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |