| abstract |
A modified interferon-.gamma. polypeptide, comprising one or more amino acid replacements in an unmodified IFN-.gamma. polypeptide at positions corresponding to any of amino acid positions 2, 5-12, 14-18, 24, 28-29, 31 , 32, 35, 36, 39, 44, 45, 48, 51 , 53-55, 57, 59, 60, 62, 63, 71-80, 83, 84, 89-99, 100, 101 , 105, 106, 109, 115, 117, 122, 123, 125, 128, 131-134, 137-139, 142, 143 of a mature interferon-.gamma.. The modification results in an increased stability of the protein. The modified interferon-.gamma. polypeptide is used for the treatment of a disease or condition selected from among a viral infection, a bacterial infection, a fungal infection, a protozoa infection, a cancer, idiopathic pulmonary fibrosis, a fibrotic condition, a hyper-IgE condition, malignant osteopetrosis and chronic granulomatous. |