abstract |
The invention relates to compounds of formula I, (see formula I) wherein Ar represents a mono or binuclear aromatic homo- or heterocycle, having 1-4 N, O- and/or S-atoms and 5-10 structural atoms which can be substituted, one, two or three times, A represents an unbranched or branched or cyclic alkyl having 1-14 C-atoms, wherein one or two CH2-groups can be replaced by O- or S-atoms and/or by CH=CH- groups and/or also, 1-7 H-atoms by F and/or CI, Hal represents F, CI, Br or I, D represents NH, NH2, NA2, NHA1, CH2, CH3, OH, OA, O or S, E represents CH2, CH, NH or N, Y represents E or a saturated or unsaturated bond, X represents CH2, O or NH, Q represents Hal, A, OH, OA, NH2, NHA, NA2, NO2, CN, OCN, SCN, COOH, COOA, CONH2, CONHA, CONA2, NHCOA, NHCONH2, NHSO2A, CHO, COA, SO2NH2 or X-M, M denotes an organic radical consisting of 2 to 40 atoms, at least one atom of which is neither a carbon atom nor a hydrogen atom, g denotes 0, 1 or 2, and ~ denotes a single or double bond. The invention also relates to the production and use thereof for producing a medicament for treating illnesses, in particular tumours and/or illnesses, wherein the development or progression of the kinases are involved. |