| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df5ca9f22c445d303811b36a40eb348e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_19dbd05e752c4bdcc42a64b8e1b19230 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 |
| filingDate |
2006-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44b14eecf0f91960fac02af4a06a2cb6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65ed091947ce509ca28e6a676e135991
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a18ea6b13d52f1106ca5a35c4c719bb7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3ea9f53f3e2b3cceb084d9fdfc46e7b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee7a752bd69d074b876c64c59be12cdf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a08dc1e2363c4d24364540aab0fd2a2e |
| publicationDate |
2015-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2602611-C |
| titleOfInvention |
Methods of producing proteins having triple-helix structure |
| abstract |
An objective of the present invention is to provide methods of producing human collagen molecules that are easy to isolate and purify and that have a structure substantially equivalent to that of a natural collagen molecule, wherein host cells that are transduced with a collagen gene synthesize large amounts of human collagen protein derived from a gene introduced into a high exogenous gene expression vector. Another objective of the present invention is to provide collagen molecules produced by the production methods. The present inventors discovered that a large amount of human collagen hardly contaminated with host cell-derived collagen could be produced, by selecting from various mammalian cells a host cell that has low collagen expression and introducing a collagen gene construct into a vector capable of high exogenous gene expression. |
| priorityDate |
2005-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |