abstract |
A microparticle containing an amphiphilic polymer, composed of an internal nucleus consisting of a hydrophilic segment of the amphiphilic polymer and a hydrophobic outer layer consisting of a hydrophobic segment of the amphiphilic polymer, wherein a surface modifier binds to the hydrophobic outer layer. This microparticle effectively encloses a hydrophilic large-molecular-weight-having protein/peptide pharmaceutical, nucleic acid pharmaceutical, etc. in the internal nucleus consisting of a hydrophilic segment of amphiphilic polymer, thus being suitable for in vivo stabilization and absorption promotion. |