http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2598271-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6e049624b468cbd0fb1c8895e4f2574 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-10 |
| filingDate | 2006-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a22d57b531f097ae85707a6836cfe258 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e8b1c96f69e5dba8b380b4a369ce369 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_102b209cb7e40ede54c7032d06179ffc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_071c503393906e130e51d57f5ea8856d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_584a84b869dc1f6ea457e1c718713f6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_061cdd401df2da2b4b6087f9bef643a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ffb20e9aeddd8681926ab0842c05523 |
| publicationDate | 2006-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2598271-A1 |
| titleOfInvention | Pharmacokinetically improved compounds |
| abstract | A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or pharmaceutically acceptable salt, stereoisomer, or hydrate thereof, wherein R1 is lower alkyl, R2 and R3 are independently selected from lower alkyl, and lower alkenyl and lower alkynyl, wherein the lower alkyl, lower alkenyl, and lower alkynyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO2, amino, acylamino, amido, carbonyl, and alkylthio, A is N or C-H, B is N, C-H, C-(SO2-R4), or C-CO-R4, D is N, C-H, C-(SO2-R4) or C-CO-R4, E is N or C-H, wherein only one of A, B or E may be N, and one of B or D is C-(SO2-R4) or C-CO-R4, R4 is a group having the formula: in which each R , R , R and R are independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO2, amino, acylamino, amido, carbonyl, and alkylthio; and additionally or alternatively R6 and R5 together form a 5- or 6-membered ring, or R6 and R7 together form a 3 to 6 membered ring; R9 is independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO2, amino, acylamino, amido, carbonyl, and alkylthio; alternatively R and R together with the nitrogen to which they are attached form a 5- or 6-membered ring; n is 1 to 4; and m is 1 to 6. |
| priorityDate | 2005-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 181.