http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2597350-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b9d212083c297d5c75d3b97ac90a50f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate | 2006-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afc1d41b865f308bb12d44eed0d697f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13ace6cdfa005c2a43e54642273524ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_593634a1e8f45c35b101d3d10a63e0cb |
| publicationDate | 2006-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2597350-A1 |
| titleOfInvention | Process for purifying noroxymorphone compounds |
| abstract | The invention relates to a method for purifying plant extracts that are substantially composed of noroxymorphone compounds and that contain in the a,~ position unsaturated noroxymorphones as contaminants. The method comprises the following steps: (a) reacting the plant extract or the product of a subsequent step in synthesis of a selected noroxymorphone compound in a reaction by which the hydroxyl groups present in the mixture are converted to leaving groups of the formula -OR2, wherein R2 represents the inserted group of the leaving group; (b) optionally removing the leaving groups; (c) subjecting the mixture thereby obtained to a selective hydration so that a saturated bond is formed in the .alpha.,~ position of the unsaturated noroxymorphone compound and the remaining present leaving groups are each converted to a hydroxyl group; and then optionally (d) isolating the pure noroxymorphone compound. The invention also relates to the manufacture of the noroxymorphone so purified to naltrexone or naloxone or to a salt of these compounds or to a quaternary derivative of these compounds. The invention finally relates to the pharmaceutical compositions comprising the inventive compound. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8058439-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7875719-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7906647-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011516464-A |
| priorityDate | 2005-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 140.