| abstract |
The present invention relates to a fumagillol derivative, pharmaceutically acceptable salt thereof and a method for preparing the same. The compounds of the present invention can be prepared through acylation, hydrolysis and alkylation. And the compound of the present invention can be prepared in the form of pharmaceutically acceptable salt or inclusion compound. The present invention provides with fumagillol derivative having more excellent inhibiting effect on angiogenesis, low toxicity, excellent solubility and chemical stability as compared to conventional angiogenesis inhibitors, and the preparation method thereof. The compounds of the present invention can be used as an anti-cancer medicine, inhibitor of cancer metastasis, or the therapeutic agent for treating rheumatic arthritis, psoriasis, diabetic retinitis or obesity. |