| abstract |
The invention relates to a process for the production of dicarboxylic acids (DCA) long hydrocarbon chains, also called diacids, in which in culture a mutant strain of Yarrowia lipolytica obtained by mutagenesis directed and more particularly disrupted at least for the POX2, POX3, POX4 and POX5 coding for Pacyl-CoA oxidase, in a medium consisting of essentially an energy substrate which comprises at least one source of carbon and a nitrogen source and said strain is subjected to a substrate of bioconversion selected from n-alkanes of at least 10 carbon atoms, fatty acids of at least 10 carbon atoms, their alkyl esters and natural oils. |