| abstract |
4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-diyhdroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process. (I) |