http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2576009-C
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5ffa3f9d6b87e15e0a1551fb129b531 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-51 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-51 |
| filingDate | 2005-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8efbc1c278630214c1ac6c772cc2fa97 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4437a72ed786a78ed657dfbe0229a225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff580bc019545a4fe1930e6b05ad38ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bb948fba2c95f9b558c396067bd1def http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd525db4083146979e8f26008a0fac15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83695ecba47c2e561d1638f235edafa8 |
| publicationDate | 2013-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2576009-C |
| titleOfInvention | Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases |
| abstract | The present invention concerns novel derivatives of 1-phenylalkanecarboxylic acids of formula (I) (see formula I) wherein: B is H or the side chain of an alpha-amino acid; R and R1 are the same and are linear or branched C1-C4 alkyl; or they form a 3 to 6 carbon atoms ring with the carbon atom to which they are linked; R2 is H, CF3, OCF3 or a halogen selected from the group of F, Cl, Br, and I, Ar is phenyl substituted with one or more groups R3 wherein R3 represents: halogen as previously defined; CF3; C3-C8 cycloalkyl optionally substituted with one or more C1-C4 alkyl and/or oxo groups; CH=CH2; NO2; CH2OH; CN; methylenedioxy; ethylenedioxy; phenyl optionally substituted with one or more of the following groups: halogen as previously defined; CF3; OCF3; OH; linear or branched C1-C4 alkyl; a saturated heterocycle with at least 4 carbon atoms and at least 1 heteroatom; C3-C8 cycloalkyl optionally substituted with one or more linear or branched C1-C4 alkyl groups, CF3 and/or OH; OR4 or NHCOR4 wherein R4 is CF3, linear or branched C2-C6 alkenyl or alkynyl; benzyl; phenyl optionally substituted with one or more of the following groups: halogen as previously defined, CF3, OCF3, OH, linear or branched C1-C4 alkyl; a saturated heterocycle with at least 4 carbon atoms and at least 1 heteroatom; C3-C8 cycloalkyl optionally substituted with one or more linear or branched C1-C4 alkyl groups, and/or OH; SR5, SO2R5 or COR5 wherein R5 is linear or branched C1-C6 alkyl; or Ar is a heterocycle selected from the group consisting of pyrrole, pyrazole, furan, thiophene, indole, isoindole, benzofuran, benzothiophene, imidazole, oxazole, isoxazole, thiazole, benzoimidazole, benzoxazole, benzothiazole, pyrimidine, pyrazine, quinoline, isoquinoline, quinazoline, quinoxaline, dibenzofuran, dibenzothiophene, thianthrene, carbazole, pyridazine, cinnoline, phthalazine, 1,5--naphthiridine, 1,3-dioxole, 1,3-benzodioxole, said heterocycle being optionally substituted with one or more groups R3 as defined above. The invention also provides for pharmaceutical compositions thereof, a process for their preparation and their use for the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease. |
| priorityDate | 2004-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 133.