http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2574103-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-197 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C259-10 |
| filingDate | 1995-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38889510f3584875cab02c5b3216ec47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6016e6291064f4d108160d1095e1788 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae23d093987237ea6e47a54701feed2d |
| publicationDate | 1995-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2574103-A1 |
| titleOfInvention | Novel potent inducers of terminal differentiation and methods of use thereof |
| abstract | The present invention provides the compound having structure (I), wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiazoleamino group; when R1 and R2 are different, R1 = R3-N-R4, wherein each of R3 and R4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R3 and R4 bond together to form a piperidine group and R2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above. |
| priorityDate | 1994-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 154.