| abstract |
The present invention includes the selection and isolation of thioaptamers that target the signaling protein TGF-~ l, compositions of such thioaptamers and the use of such thioaptamers to either block or enhance signal transduction of the TGF-~l protein and thus function as, e.g., immunomodulatory agents. Thioaptamers may also be targeted alone or in combination with other thioaptamers against the ligand, the receptors, the ligand trap protein(s) and/or the co-receptors to modulate TGF-~ signaling pathway. |