| abstract |
The invention provides a substituted cyclohexyl-1,4-diamine derivative of formula I (see formula I) The derivative may be used for treatment of pain, for example acute, neuropathic or chronic pain. The derivative may also be used for treatment of an anxiety state, stress, a stress-associated syndrome, depression, epilepsy, Alzheimer's disease, senile dementia, catalepsy, a general cognitive dysfunction, a learning disorder as a nootropic, a memory disorder as a nootropic withdrawal symptoms, alcohol abuse, alcohol dependency, drug abuse, drug dependency, medicament abuse, medicament dependency, a sexual dysfunction, a cardiovascular disease, hypotension, hypertension, tinnitus, pruritus, migraine, impaired hearing, deficient intestinal motility, impaired food intake, anorexia, obesity, a locomotor disorder, diarrhoea, cachexia, or urinary incontinence. The derivative may be used as a muscle relaxant, anticonvulsive or anaesthetic; for co-administration with treatment with an opioid analgesic or an anaesthetic; for diuresis, antinatriuresis or anxiolysis; for modulation of movement activity; for modulation of neurotransmitter secretion and treatment of a neurodegenerative disease associated therewith; or for one or both of treatment of withdrawal symptoms and reducing addiction potential of opioids. |