| abstract |
The present invention relates to a substituted cyclohexylcarboxylic acid derivative of formula I (see formula I) The derivative may be used for treatment of pain, in particular acute, visceral, neuropathic or chronic pain. The derivative may also be used for treatment of anxiety, stress, a stress-related syndrome, depression, catalepsy, epilepsy, Alzheimer's disease, senile dementia, general cognitive dysfunction, a learning difficulty as a nootropic, a memory difficulty as a nootropic, withdrawal symptoms, alcohol abuse, alcohol dependency, drug abuse, drug dependency, medicine abuse, medicine dependency, sexual dysfunction, cardiovascular disease, hypotension, hypertension, tinnitus, pruritus, migraine, a hearing difficulty, deficient intestinal motility, impaired nutrient absorption, anorexia, obesity, a locomotive disorder, diarrhoea, cachexia or urinary incontinence. The derivative may be used as a muscle relaxant, an anti-convulsive or an anaesthetic for co-administration in treatment with an opioid analgesic or anaesthetic; or it may be used for diuresis, anti-natriuresis, anxiolysis, modulation of motor activity, modulation of neurotransmitter release and treatment of a neurodegenerative disease associated therewith or for one or both of treatment of withdrawal symptoms and reducing potential for addiction to opioids. |