Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec278f55741bfdd6fb9ab250e90b8085 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-44 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
filingDate |
2005-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2015-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5edd8ae49b1dbcb73184c5e3d58908eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13d030b9cd17a59dd85228673430890e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b3c752423af7a2ad5b4f2bb3be17f6d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0d987835c6e8b12b9d58e0de2368065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_113dde1138ad378dd97bfe2cd068ebcc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c645d66243e9a4bedba77c118b024b61 |
publicationDate |
2015-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CA-2561504-C |
titleOfInvention |
Modified cells that co-express blimp1 and a reporter molecule and methods of using the same |
abstract |
In one aspect, the present invention provides a genetically modified cell or non-human organism comprising such cells comprising modified genetic material which when expressed produces a polypeptide co-expressed with a reporter molecule and wherein the polypeptide is associated with terminal differentiation of a haematopoietic cell. Preferably, the genetic material gene is a Blimp allele or a part, fragment or functional form thereof. Furthermore, the identification of the reporter molecule in B-cell lineage cells indicates that such cells are committed to differentiate or have differentiated into ASC. Alternatively, reporter molecule activity in cells of a T cell lineage indicates that these cells are activated. Thus, as described herein, the presence of Blimp in a lymphocyte indicates that the cell is terminally differentiated or is committed to terminal differentiation. Exemplary T-cells include CD4+ T-cells and CD8+ T-cells and exemplary B-cells are ASC. |
priorityDate |
2004-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |