| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3fdaffe64e0056ceff97698a913ed913 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-179
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1136 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate |
2005-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4ab8b4291b166b2504cde777263f419
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f8e7f945203c29f1765a3a065912c00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_521a32c038faf8e6641cdf958d2a3985
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf2e03d6c1ee8e7c83158bed598aa5af
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23ca159e489758486d7c21f088159f71 |
| publicationDate |
2005-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2560046-A1 |
| titleOfInvention |
Methods for suppressing tumor proliferation |
| abstract |
It is intended to provide a method of inhibiting tumor proliferation which comprises the step of inhibiting the expression of PDGF-A or the binding of PDGF-A homodimer to PDGFR.alpha.. Activation of the PDGFR .alpha.-p70S6K signal transfer pathway by PDGF-AA, which is an important factor in tumor angiogenesis, relates to the prognosis of a patient suffering from tumor. By inhibiting the expression of PDGF-A in a tumor or a tissue around it or by inhibiting the binding of PDGF-A homodimer to PDGFR.alpha., angiogenesis in the tumor and retention of the blood vessels can be inhibited and thus the tumor proliferation can be inhibited. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8754195-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8697664-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7754859-B2 |
| priorityDate |
2004-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |