| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_360bdb4b2f4bd10ffa4410a71bb72af1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N24-088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N24-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-4608 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B70-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N24-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B50-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-483 |
| filingDate |
2004-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2012-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_159771faa824f8c4a7093f786b588cce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf91ba8c680c6315cdbf6b3a0d1321d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_607fa474fc5dd70fe2fd3f7c4eee4040
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cf2604a6cf52b2d5197277ca39d80f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71eb9043b9366d4728024c305e470c73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3e5173d7c0285b7b71661dc7a86a8c7 |
| publicationDate |
2012-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2559711-C |
| titleOfInvention |
Nuclear magnetic resonance assembly of chemical entities using advanced antenna probes |
| abstract |
The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds specifically to a macromolecular target; (b) providing a sample comprising the macromolecular target, the first ligand and a candidate second ligand under conditions wherein the first ligand and the macromolecular target form a bound complex; (c) detecting a subset of magnetization transfer signals between the antenna moiety of the first ligand and the second candidate Iigand, wherein the signals are obtained from an isotope edited NOFSY spectrum of the sample; thereby determining that the two ligands are proximal in a bound complex, and identifying a second ligand that binds to the macromolecular target. |
| priorityDate |
2003-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |