http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2554782-C
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60da379fb33c192ef77f86a60c5ac029 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-16 |
filingDate | 2005-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2013-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4fc2acc23d36d605bf498834c2316a67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a245f56fc581b5a615a4633b6360ac48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bcf3681c50d6124b35811496d24ae84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5370eb050b78aba6802a7d7239556011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c868d2192c58328b80b216a2b33262c2 |
publicationDate | 2013-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CA-2554782-C |
titleOfInvention | Methods to manufacture 1,3-dioxolane nucleosides |
abstract | This aplication provides a process for preparing enantiomerically pure .beta.-D-dioxolane nucleosides. In particular, a new synthesis of (-)-DAPD, suitable for large scale development, is described. In one embodiment the invention provides a process for preparing a substantially pure .beta.-D or .beta.-L-1,3-dioxolane nucleosides comprising a) preparing or obtaining an esterified 2,2-dialkoxy ethanol; b) cyclizing the esterified 2,2-dialkoxy ethanol with glycolic acid to obtain a 1,3-dioxolane lactone; c) resolving the 1,3-dioxolane lactone to obtain a substantially pure D- or L-lactone; d) selectively reducing and activating the D-or L-chiral lactone to obtain a substantially pure D- or L-1,3-dioxolane; e) coupling the D- or L-1,3-dioxolane to an activated and/or protected purine or pyrimidine base; and f) optionally purifiying the nucleoside to obtain a substantially pure protected .beta.-D or .beta.-L-1,3-dioxolane nucleoside. |
priorityDate | 2004-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 456.