| abstract |
An adenosine A2A receptor antagonist which contains as an active ingredient either a thiazole derivative represented by the following general formula (I ): (I) (wherein n is an integer of 0 to 3; R1 represents (un)substituted cycloalkyl, (un)substituted aryl, (un)substituted alicyclic heterocyclic group, or (un)substituted aromatic heterocyclic group; R2 represents halogen o, (un)substituted lower alkyl, (un)substituted aryl, (un)substituted alicyclic heterocyclic group, (un)substituted aromatic heterocyclic group, -COR8, etc. ; and R3 and R4 are the same or different and each represents hydrogen, (un)substituted lower alkyl, (un)substituted aralkyl, -COR12, etc.) or a pharmacologically acceptable salt of the derivative. |