| abstract |
The subject of the invention is nucleic acid constructs, characterized in that they comprise nucleic acids isolated in the sense position, capable of encoding an immunogenic protein of promastigote or amastigote forms of Leishmania, said nucleic acids responding to one sequences SEQ ID N ~ 1, SEQ ID N ~ 2, SEQ ID N ~ 3, SEQ ID N ~ 4, SEQ ID N ~ 5 and SEQ ID No. 11 and coding for a protein having, respectively, a sequence SEQ ID N ~ 6, SEQ ID N ~ 7, SEQ ID N ~ 8, SEQ ID N ~ 9, SEQ ID N ~ 10 and SEQ ID N ~ 12. Application for overexpression of Leishmania genes encoding a excretion / secretion antigen. |