Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f244c6155c2c1d73694b62b1c889927 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
filingDate |
2004-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99a689b6cb36a1455766ba05b2db4236 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f349bd09fe17b5b6fe6817b6fbf341e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1be90133bacab4436be86cae87231f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_275c47f0eaa0338e9da6c8c37f8bbe23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecdde7716f39d1e46460598cd48e905a |
publicationDate |
2005-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
CA-2536078-A1 |
titleOfInvention |
Rnai-based modification of heterochromatin |
abstract |
Methods of regulating the formation of heterochromatin at a target locus within the genome of a cell and methods of regulating the modification of a histone protein assumed on the DNA of a target locus within the genome of a cell are provided. In particular, the invention provides methods to regulate the structure of the genome of a cell, where the structure is regulated by modulating heterochromatin formation, heterochromatin architecture, histone methylation, and/or DNA methylation, by exposing the cell to an RNAi probe complementary to a target locus so as to activate the RNAi machinery to modify the genomic structure of the target locus and adjacent segments of the genome. |
priorityDate |
2003-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |