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publicationDate 2004-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CA-2515585-A1
titleOfInvention Enteric sustained-release fine particles for tamsulosin or its salt and manufacturing method thereof
abstract Enteric sustained-release fine particles for tamsulosin or its salt, which can be incorporated in an intraorally disintegrable tablet, and a process for producing the same. In particular, enteric sustained-release fine particles for use in intraorally disintegrable tablets, comprising (1) tamsulosin or its salt and at least (2) an enteric substance, optionally together with (3) a water insoluble substance, characterized in that: 1) the particles are those whose average diameter is in the range of about 5 to 250 µm; and 2) when with respect to intraorally disintegrable tablets containing the particles a dissolution test thereof is performed in accordance with the dissolution testing method specified in the Japanese Pharmacopoeia; a) the dissolution ratio of tamsulosin or its salt two hours after the test initiation at pH 1.2 is 25% or below; and b) the time wherein 50% of tamsulosin or its salt is dissolved at pH 6.8 is in the range of 0.5 to 5 hr; and a process for producing the same.
priorityDate 2003-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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