| abstract |
The present invention discloses open reading frames (ORFs) in human genome encoding for novel fibrillin-like polypeptides, and reagents related thereto including variants, mutants and fragments of said polypeptides, as well as ligands and antagonists directed against them. The invention provides method s for identifying and making these molecules, for preparing pharmaceutical compositions containing them, and for using them in the diagnosis, preventio n and treatment of diseases. |