| abstract |
The present invention provides compounds capable of binding to an Fc recepto r and modulating Fc receptor activity comprising a core lipophilic group in th e form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the Fc.gamma.RIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor. |