| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71c1c36897edd451262ce1e26c6dedcd |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-02 |
| filingDate |
2003-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2013-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68e40cfc613f0624017cde7c104570dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e260a1302d4f0f9cccb5abe50d84d57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1ddb0aaec0b27b3299dea7d5ee83acf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a68e5c1136b3361bb75aaed86633be7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be1524a5708e708d8b7ce965cfa23177 |
| publicationDate |
2013-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2510184-C |
| titleOfInvention |
In vivo affinity maturation scheme |
| abstract |
The present invention relates to the field of evolution of nucleic acids in vivo and provides methods and compositions for introducing diversity into gene products. The present invention allows generation of new sequences that have desirable properties by virtue of high frequency mutation events within a cell. The high frequency mutation of a polynucleotide sequence results in the production of a large population of new sequence variants. Appropriate selection and/or screening permits identification and isolation of mutant forms of the polynucleotide sequence as well as products resulting from expression of the mutant sequences. |
| priorityDate |
2002-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |