| abstract |
Analogues of valproic acid useful in treating neuroaffective disorders including convulsions, bipolar disorder, and migraine headache are disclosed . The analogues are halide substituted analogues, cyclic analogues, and conjugated diene analogues of valproic acid. Pharmaceutical compositions or prodrugs containing the analogues or pharmaceutically acceptable salts there of are disclosed. Methods of making the compounds and treating mammals with neuroaffective disorders are also disclosed. |