| abstract |
Control of AMPK activity enables interventions that modulate lifespan regulation. Agents which alter lifespan regulation of a cell or organism are identified by screening for compounds that regulate AMPK activity or AMPK pathway activity. The agents so-identified and compounds known to alter AMPK pathway activity can be administered to a subject, e.g., to alter lifespan regulation in the subject or to affect a longevity-associated disorder, or a risk, symptom, predisposition thereof. |