http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2506919-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1d350625286def8f8f8172a3d67dd0ca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2003-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30e7a7c4fae51ad120ebe6474b05b419 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2a05140ea2804aacb6bddf3ca24e316 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_129b24214a52bbebf2e3df66b4ceddb2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d923b1a90deb6d2dba388875f121da38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c613b2d1302ee55885d82916b3d201f |
| publicationDate | 2004-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2506919-A1 |
| titleOfInvention | Detection of cellular or dna damage based upon hr23 protein binding molecules |
| abstract | The invention provides a method for determining whether an agent is capable of inducing a DNA lesion in a eukaryotic cell, comprising: - exposing at least one eukaryotic cell to said agent, and - determining whether a HR23 protein binding molecule accumulates within said cell. It is preferably determined whether xeroderma pigmentosum group C protein (XPC), 3-methyladenine DNA glycosylase (MAG), CREB, p53, or a functional part, derivative and/or analog ue thereof, accumulates in the nucleus of said cell. Preferably, said cell is overexpressing a HR23A and/or HR23B protein. With a method of the invention, a rapid and sensitive test is provided with significant advantages over the widely used Ames test. The invention also provides a method for determining whether an agent is capable of at least in part inhibiting a cellular proces s, said process resulting in accumulation of HR23 protein binding molecule with in a cell, comprising exposing a eukaryotic cell to said agent, and determining whether a HR23 protein binding molecule such as XPC, MAG, CREB and/or p53 accumulates within said cell. A method for determining whether a cell has an impaired DNA repair system is also provided. An impaired DNA repair system i s indicative for diseases such as xeroderma pigmentosum, cockayne syndrome, and/or trichothiodystrophy. |
| priorityDate | 2002-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 647.