| abstract |
Disclosed is an amide compound of the formula: wherein X is a divalent group such as O, S, or the like; M is arylene, cycloalkylene or divalent heterocyclic group; R1, R2, R3 and R4 are each hydrogen or substituent, provided that at least one of them is substituent; R5 is H, alkyl, aralkyl or amino-protecting group; m is an integer of 0-6; R6 is aryl, cycloalkyl, alkyl, alkoxy or the like; and R7 is aryl, heterocyclic group or -CO(Y)p R12 in which Y is O, S, NH or the like, p is 0 or 1 and R12 is H, alkyl, aryl, aralkyl or the like. The amide compound is useful as an intermediate for producing another amide compound having a similar structure but having R-A-X- in place of HX- in which R is heterocyclic group or the like and A is a bond or an alkylene group. The other amide compound is useful as an anti-inflammatory agent. |