http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2500635-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_330b09678de89190c85b7d8c1d4d05f4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02 |
| filingDate | 2003-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa3a2eaf5b3b2348c260c9d51581fff6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f21d8fd5946640f78bfc430e1a8de64 |
| publicationDate | 2004-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2500635-A1 |
| titleOfInvention | Process for the preparation of (s,s)-cis-2-benzhydryl-3-benzylaminoquinuclidine |
| abstract | A process for preparing (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine. Th e process includes the steps of contacting a compound containing a mixture of R- and S-isomers and having Formula (I), with an effective amount of a chiral organic acid in the presence of an organic solvent and an effective amount o f an organic carboxylic acid for converting the R-isomer into an acid salt of the S isomer, wherein the organic solvent is capable of solubilizing the compound containing the mixture of R- and S-isomers, while precipitating the acid salt and the organic carboxylic acid is different from the chiral organ ic acid; neutralizing the acid salt with a base to provide an S-isomer of a chiral ketone of Formula (II), and reacting the chiral ketone with an organi c amine in the presence of a Lewis acid to provide the corresponding imine and reducing the imine. |
| priorityDate | 2002-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 105.