http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CA-2498978-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a23032a0d3404f90cbe4ca57c9ea8d6f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 |
| filingDate | 2005-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fedf30639651cf6094a50421d14230b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7eab0bef0559d9700cd12d37d0136dab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afbd55774f9f4cd6193273d3ced72f71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b794b008d046159a04a5361308a866c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77f3f151826c2b83b4a1a21ec0a1091c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79dc963a70cb42928592ca4f27054c40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec7e646c68c97b1e4b2218bd30c7f051 |
| publicationDate | 2006-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CA-2498978-A1 |
| titleOfInvention | An improved process for the preparation of atorvastatin and intermediates |
| abstract | A process is provided for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, R-substituted ester 9 comprising: (a) reacting the aldehyde 1 with the enolate form of (S)-2-hydroxy-1,2,2-triphenylethyl acetate substituent in a chelating co-solvent; See Formula 1 (b) hydrolysis of (R,S)-5-[2-{4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid, (S)-2-hydroxy-1,2,2-triphenylethyl ester (2a and 2b) using a base, preferably an alkali metal base, preferably in a solvent to form the carboxylic acid 7; See formula 2 (c) treating the acid 7 with a chiral base to form a salt and purifying the salt to obtain enantiomerically enriched (R)-7 chiral base salt; See formula 3 (d) alkylation of the (R)-7 chiral base salt or the free base derived from (R)-7, forming (R)-S-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-S-hydroxy-3-oxo-1-heptanoic acid, R-substituted ester 9 and atorvastatin calcium 6, (see formula I) wherein R is a C1 to C6 alkyl, C6 to C9 aryl or C7 to C10 aralkyl. |
| priorityDate | 2005-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.