| abstract |
The present invention is directed to heterocyclic amidines of formula (I) (see formula I) where one of G1 and G2 is an amidine substituent of formula Q (see formula Q). Compounds according to the invention exhibit anti-inflammatory and analgesic activity and inhibit nitrogen oxide production. The invention is also directed to the use of these compounds and corresponding pharmaceutical composition for the treatment of rheumatoid arthritis, osteoarthritis, pain of articular or neuropathic origin and inflammatory diseases of the gastrointestinal tract. |