| abstract |
The invention relates to novel heterocyclic derivatives, processes for their preparation, ad their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development. Specifically, the invention relates to compounds of the general formulas (I-A) and (I-B) (see formula I-A) (see formula I-B), wherein A represents an aryl or heteroaryl ring, R1, R2 and R3 independently from each other represent hydrogen, halogen, nitro, cyano, C1-C6-alkyl, hydroxy or C1-C6-alkoxy, R4 represents C1-C6-alkyl, etc., R5 represents C1-C4-alkyl, etc., R6A represents hydrogéna, C1-C6-alkylcarbonyl, C3-C8-cycloalkylcarbonyl, etc., R6B represents C1-C6-alkyl, etc., R7 represents halogen, nitro, cyano, C1-C6-alkyl, hydroxy or C1-C6-alkoxy, and Y1, Y2, Y3 and Y4 independently from each other represent CH or N, wherein the ring contains either 0, 1 or 2 nitrogen atoms. |