| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a135a933620c99beab01d4ac785d25 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-20 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01147
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2434
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2402
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01021
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2494 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-64 |
| filingDate |
2003-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eded5dfdd9707af7737daa66a72900ed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ea6bf451104b578ee32391333a52ced |
| publicationDate |
2004-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2497881-A1 |
| titleOfInvention |
Engineered enzymes and their use for synthesis of thioglycosides |
| abstract |
Mutant glycosidases in which the amino acid in the active site that serves as the acid, base or acid/base-catalyst is converted from a carboxylic acid to some other amino acid (for example to a simple alkyl, as in alanine or glycine) can catalyze the reaction of a thiosugar acceptor and an activated donor to form a thioglycoside. The "thioglycoligases" represent a novel class of mutant enzymes, and represent a first aspect of the invention. Thioglycoligases can be used in accordance with the method of the invention to couple a thiosugar acceptor and an activated donor to form a thioglycoside. By selection of the donor and acceptor species, as well as the specific enzyme employed, thioglycosides of different structure and stereochemistry can be obtained. |
| priorityDate |
2002-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |