| abstract |
A pyrazole derivative represented by the general formula (I) (wherein R1 is H, optionally substituted C1-6 alkyl, etc.; either of Q and T is the group of t he formula (II) or the formula (III) and the other is optionally substituted C1 -6 alkyl, etc.; R2 is H, halogeno, OH, optionally substituted C1-6 alkyl, etc.; X is a single bond, O, or S; Y is a single bond, C1-6 alkylene, etc.; Z is CO or SO2; R4 and R5 each is H, optionally substituted C1-6 alkyl, etc.; and R3, R 6, and R7 each is H, halogeno, etc.), a pharmacologically acceptable salt of th e derivative, or a prodrug of either. They have excellent human SGLT1 inhibito ry activity and are useful as a preventive or therapeutic agent for diseases attributable to hyperglycemia such as diabetes, complications of diabetes, a nd obesity. |