| abstract |
A medicament having inhibitory activity against NF-.KAPPA.B activation which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I-1) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: (see formula I-1) wherein "A1" represents an acyl group which may be substituted, (provided that unsubstituted acetyl group and unsubstituted acryloyl group are excluded,) or a C1 to C6 alkyl group which may be substituted, "E1" represents an aryl group which may be substituted or a heteroaryl group which may be substituted, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula -O-A1 wherein A1 has the same meaning as that defined above and the group represented by formula -CONHE1 wherein E1 has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula -O-A1 wherein A1 has the same meaning as that defined above and the group represented by formula -CONHE1 wherein E1 has the same meaning as that defined above. |