| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81bf700a57076c9c99876dcd24dd8b23 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2003-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d381222faa7f64140bab7559fabd6bd3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f71b85aac7e13a961257cbe25cee66a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14500e5290ec8db8f942904a0a26eea1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2175fccd3fdf887a749daca38dd3b167 |
| publicationDate |
2003-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CA-2487342-A1 |
| titleOfInvention |
Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation |
| abstract |
The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs o f oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making t he convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product. |
| priorityDate |
2002-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |