| abstract |
This invention discloses and claims substituted 3-amino-2-carboxylic acid indole and benzo(b)thiophene derivatives for use in treating allergy, asthma , rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. In preferred embodiments of this invention it is also disclosed and claimed tha t the compounds of this invention are capable of modulating T helper (Th) cell s, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin- 4 (IL-4) message, IL-4 release or IL-4 production. |