| abstract |
A phosphodiesterase IV inhibitor which contains as an active ingredient eith er a pyridylacrylamide derivative represented by the following formula (I): (I) (wherein Ar1 represents (un)substituted pyridyl; Ar2 represents phenyl substituted by alkoxy, etc.; R1 represents hydrogen, alkyl, or aryl; R2 represents hydrogen, alkyl, cyano, or alkoxycarbonyl; R3 represents hydrogen or optionally substituted alkyl; X represents oxygen or sulfur; A and B are the same or different and each represents hydrogen, hydroxy, alkoxy, or alkylthio, or A and B both in cooperation represent oxo, thioxo, etc., provided that when A is hydroxy, then B may be 1-alkylimidazol-2-yl; and n i s an integer of 1 to 3) or a pharmaceutically acceptable salt of the derivativ e. |