| abstract |
The object of the invention is to provide a particulate multi (micro) tablet, comprising a heart of active ingredient PA mechanically non-deformable (crystal, granule), allowing the prolonged release in vivo of this PA, without modification of the release profile by compression (microparticles not specifically formulated for compression). This goal is achieved by tablet according to the invention, on the basis of reservoir microcapsules, prolonged AP, and: "each formed by a non-deformable core comprising PA and covered by at least one coating film controlling the prolonged in vivo release of AP, having a particle size of between 50 and 1000 ~ m "and comprise at least one outer shell of overcoating based on at least one deformable organic constituent having a melting temperature of between 40 ~ C and 120 ~ C (polyethylene glycol). Over-coated microcapsules resistant to compression are also referred to as such by the invention. |